Prospective Utilization of Wharton’s Jelly-Derived Mesenchymal Stem Cells and Their Conditioned Medium in the Regeneration of Diabetic Corneal Neuropathy

Diabetes Mellitus, a highly prevalent and rapidly increasing metabolic disease, can cause several serious complications including visual damage blindness caused by ocular nerve damage. Nerve fiber degeneration might occur because of the accumulation glycation end-products in Descemet’s membrane nerve. The severity corneal diabetic keratopathy be examined through regeneration nerves, specifically GAP-43 TUB33, which are two markers regeneration. WJMSCs (Wharton’s jelly-derived mesenchymal stem cells) induce its regenerative effects expressing genes that promote neuronal development, inhibiting proliferation pro-inflammatory cytokines, suppressing immune system, most all proliferative capacity. believed to more superior than other sources cells as umbilical cord is easily accessible stored for further usage. Moreover, possess anti-tumorigenic abilities does not any adverse effects. Thus, prospective utilized neuropathy patients bright, but trials still needed solidify efficacy.